Returning participant

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If the study team has already filled in your details, enter the code they gave you. You'll skip straight to today's session.

Who is this? Required

First name *

Last name *

Please enter the first and last name.

Video recording consent confirmedNothing records without it.

Confirm video recording consent to continue.

2 Consents — before any recording

Record what has been signed and confirmed. Signatures live on the consent documents themselves, not here.

Dose time as reported at call open (coordinator note — the in-app check-in is the source)

Amended study consent signed *

Amended study consent signedThe version with the three separate opt-ins below.

Video opt-in (separate)

De-identified commercial / partner use

Broad re-contact

Wren research-mode consent *

Wren research-mode consent signed

Confirmed verbally *

Tick each one once it has been said out loud and acknowledged.

This study is observational only. We will never ask you to change or delay a dose. You can skip any task. You can leave at any time.

Please confirm the signed consents and all four verbal confirmations.

3 Linkage

Connect this visit to your earlier Aethel sessions.

Prior Aethel sessions — how many?

When was the last one?

Phone

Preferred contact method

Living situation

Caregiver name

Needed for the month-6 pre-dose visit.

Caregiver contact

Primary language

Comfortable reading English aloud?

For the speech task.

Any hearing difficulty following spoken app instructions?

4 Quick re-confirms

Device *

Exact make, OS, browser and camera. This device is locked for 18 months — tell them.

Make / model

Operating system

Browser

Webcam

Told: this device is locked in for 18 monthsSame device, same browser, same camera for every session.

Please record the device make, OS and browser.

Weight now

lbs

Vision correction worn now

Will you wear the same correction during every session?

Keep it constant.

Smoking status unchanged?

Anything newly diagnosed since the form?

Any condition affecting movement, stamina or balance.

Walking aid now

Any orthopedic problem, injury or surgery that limits sit-to-stand, walking, or arm swing?

Knee, hip, shoulder, back.

5 Exercise and activity

Do you exercise regularly?

Days per week

Total hours per week

Type

Select all that apply.

Usual intensity

Any structured PD program right now?

Has your exercise changed in the last 6 months?

Typical time of day you exercise

So it can be kept away from the session slot.

5b PD clinical intake

Diagnosis year

Most-affected side

Locked for the study from today. Read back their earlier answer.

Untreated?

PD medication list

LEDD (mg/day)

Formula: Schade 2020 conversion factors. Entered by the coordinator.

Non-PD medications that affect movement or tremor

Flags

Patch, overnight dosing, infusion, or a dopamine agonist means no clean washout.

DBS settings changed in the last 3 months?

Wearing-off?

How long after a dose does it start? (min)

How long does it last? (min)

Morning state before first dose — do you notice a difference?

Can you stand and walk safely before your first dose?

Dyskinesia?

Freezing of gait?

Anchor dose for the study

Which dose

Clock time

Formulation

Expected battery window

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6 Scored clinical instruments

Score each item 0–4 from the licensed MDS-UPDRS form. Item wording and anchors are not reproduced here.

MDS-UPDRS Part I

MDS-UPDRS Part IV

Hoehn & Yahr

Stage

How it was assigned

7 Room and setup

Space for a lateral walk of 30+ steps, camera side-on?

Full body visible standing?

Full hand visible for tapping?

Framing markers checked?

Straight-backed chair with arms, non-rolling?

Lighting even, no window behind them?

Internet stable?

Known-size object available for the frame?

A credit card works. Used for anatomical normalisation.

Said out loud: the camera stays on this device, in this room, in the same position

Who else is in the room?

Caregiver present today?

Time zone, in their words

Do you observe daylight saving?

Guatemala doesn't.

Permanent session slot

Same day of week, same clock time, same dose offset — every time.

Day of week *

Clock time *

Dose offset (minutes after the anchor dose)

Slot confirmed with participant

Please set the permanent slot day and time.

8 Familiarization pass

Whole battery once, unscored. Tell them it doesn't count.

Unscored pass completed Told the participant it doesn't count

Anything they struggled to follow?

9 Scored battery Every session

The battery runs on the participant's device after the in-app check-in. Order is fixed by the app; the participant paces the rest between tasks with the Continue button. Any skip logs its reason.

Stillness — 10 s
Finger tapping — 6 trials of 10 s (3 per hand, alternating; starting hand is randomized per participant and then fixed)
Pronation–supination — 4 trials of 10 s (right, left, right, left)
Sit-to-stand — practice + calibration, then 2 timed 20-s trials, arms crossed
Tremor — rest, then postural
Face — pa-ta-ka, reading passage, and expression tasks
Speech — sustained vowel, 30-s monologue
Gait — side-on, 25-s practice then 3 timed 30-s walks, back and forth

Order and skip logging explained

10 Recorded Part III exam

Read each item's instruction from the licensed MDS-UPDRS form and record it. Log anything that could not be recorded, and why.

11 Patient-reported questionnaires

MDS-UPDRS Part II

Score each item 0–4 from the licensed MDS-UPDRS form.

PGI-S — overall severity today (7-point)

Considering all the ways your Parkinson's affects you, how severe is it today?

MoCA

Administered?

Only if you are certified. Otherwise log "not administered" and the reason.

Score (0–30)

PDQ-39

Read each item from the licensed PDQ-39 form and enter the response. Item wording is not reproduced here.

12 Wren

Phone type

OS version

Installed One entry done together, in their words Structured medication schedule enteredAs they take it today: name, dose, clock times.

Notifications

What time of day would they log?

Rules said out loudNo scores. No streaks. Not paid for entries. It never tells you anything about your PD. Stop any time without leaving the study. What to log explainedFalls, illness, medication changes, bad sleep, anything that felt different.

13 Home-session instructions

Twice weeklySame device, same room, same slot. Stillness first. Dose time tapped every time. Monthly pairOnly with a clean washout: morning session before the first dose, then 60–90 min after (1.5–2.5 h for ER). Same day, same room. Pre-dose safety ruleSkip standing tasks pre-dose if unsafe. That is a logged skip, not a failure. Who to contact if the device breaks or changesLog the change. Never silently switch.

Contact for device problems

14 Close

Next session

Filled in by

Anchor dose taken with food?

Device running the video call

The app runs on the study device.

Follow-ups owed

Notes

Saves, marks the visit closed, clears this device's draft and returns home.

Welcome back.